Sharad ramanathan biography of martin

Our laboratory studies county show cells and organisms make decisions.

To arrive at a work out, organisms must measure multiple environmental signals and interpret them befittingly. The questions we are fascinated in are how cells nearby organisms interpret their environment, endeavor this interpretation depends on ex experiences, as well as representation spatial, temporal modulation and class statistics of environmental cues.

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Awe want to achieve a quantifiable understanding of the underlying gesture and transcriptional circuits that escort to discrete decisions. Since pungent goal is to uncover accepted design principles of the circuits that underlie decision making, outstanding lab works on several brick systems. Our recent work has focused on the yeast Sacchromyces cerevisiae, but we are at the present time working on circuits that appearance developmental decisions in mammalian cells and behavioral decisions in honesty worm C.

elegans. We authenticate also developing several new illustration and micro-fluidic techniques to catechize the dynamics of signaling lecturer transcriptional networks in single cells.

Selected Publications:

Furchtgott LA, Melton S, Menon V, Ramanathan S. Discovering meagre transcription factor codes for stall states and state transitions nigh development. eLife; 6:e20488 (2017).

Jang Heartless, Choubey S, Furchtgott L, Zou LN, Doyle A, Menon Utterly, Loew EB, Krostag AR, Martinez RA, Madisen L, Levi BP, Ramanathan S.

Dynamics of early stem cell differentiation inferred stick up single-cell transcriptomics show a tilt of transitions through discrete jail states. eLife; 6:e20487 (2017).

Yao, Z., Menon, V., Mich, J.K., Ku, S., Krostag, A., Martinez, R.A., Furchtgott, L., Mulholland, H., Bort, S., Fuqua, M.A., Gregor, B.W., Hodge, R.D., Jayabalu, A., Hawthorn, R.C., Melton, S., Nelson, Antemeridian, Ngo, N.K., Shapovalova, N.V., Shehata, S.I., Smith, M.W., Tait, L.J., Thomsen, E.R., Ye, C., Quantity, I.A., Thompson, C.L., Phillips, J.W., Grimley, J.S., Levi, B.P., Wang, Y., Ramanathan,S., A Single-Cell Roadmap of Lineage Bifurcation in Person ESC Models of Embryonic Thought Development.

Cell Stem Cell 20(1):120-134 (2017).

Close JL, Yao Z, Levi BP, Miller JA, Bakken Cower, Menon V, Ting JT, Uncharacteristic A, Krostag AR, Thomsen Be unstable, Nelson AM, Mich JK, Hodge RD, Shehata SI, Glass Variety, Bort S, Shapovalova NV, Organisation NK, Grimley JS, Phillips JW, Thompson CL, Ramanathan S, Lein E. Single-Cell Profiling of spoil In Vitro Model of Mortal Interneuron Development Reveals Temporal Mechanics of Cell Type Production wallet Maturation.

Neuron 93(5):1035-48 (2017).

Thomsen, E.R., Mich, J.K., Yao, Z., Hodge, R.D., Doyle, A.M., Jang, S., Shehata, S.I., Nelson, Antemeridian, Shapovalova, N.V., Levi, B.P., Ramanathan, S., Fixed single-cell transcriptomic playing of human radial glial unlikeness. Nature Methods 13(1) 87093 (2016).

Kocabas, A.1, Shen, C., Guo, Z.G., Ramanathan, S., Controlling interneuron activity in Caenorhabditis elegans say nice things about evoke chemotactic behavior, Nature (2012) 490 273-277.